عنوان مقاله:

نویسندگان:

زینب انصاری اصل، رضا سکوربراوی، زهرا شاه ولی، اسماعیل داراب پور

Nanocomposite sponges composed of biocompatible polymers and inorganic materials have attracted much attention within various fields such as biomedicine, pharmaceutics, and food packaging [1-3]. In this study, we have fabricated some novel nanocomposites with a combination of salt leaching for fabrication of PDMS sponge, in situ synthesis of Zn-MOF, and dip coating process for coating Zn-MOF@PDMS sponge with chitosan. Chitosan stabilizes Zn-MOF particles and promotes the biocompatibility of the as-obtained composites. The surface morphology of PDMS and its nanocomposites was investigated by scanning electron microscope (SEM). X-ray diffraction was conducted to study the microstructure of the prepared Chitosan@Zn-MOF@PDMS sponge. The nanocomposite sponge, Chitosan@Zn-MOF@PDMS, was also studied by elemental EDS mapping technique. The antibacterial activity of the as-prepared sponges was also evaluated. Chitosan and Zn-MOF improved the antibacterial properties of the PDMS sponges against Escherichia coli and Staphylococcus aureus. The Chitosan@Zn-MOF@PDMS sponge has the potential for antibacterial and tissue engineering purposes owing to their biocompatibility, porosity, and good mechanical stability.

Metal-organic framework; Polydimethylsiloxane; Biocompatibility

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انصاری اصل، زینب، سکوربراوی، رضا، شاه ولی، زهرا، داراب پور، اسماعیل، 1402، Preparation of chitosan-coated Zn-MOF@PDMS nanocomposites sponge for antibacterial activity، بیست و دومین کنفرانس شیمی معدنی ایران، https://conference.uok.ac.ir/fa/archive_index.php?c=HN-iicc22&aid=1517552